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Updated: Aug 3, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Factors associated with the progression of aortic valve calcification in older adults

David Leibowitz1, Yuriko Yoshida2, Zhezhen Jin3

  • 1Heart Institute, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

International Journal of Cardiology
|April 8, 2023
PubMed

Insights

Aortic valve calcification (AVC) progresses in many older adults. While common risk factors aren't linked, higher TGF-β1 levels are associated with AVC progression.

Area of Science:

  • Cardiology
  • Gerontology
  • Biomarker Research

Background:

  • Aortic valve calcification (AVC) is a common valvular abnormality leading to stenosis.
  • Progression of AVC and its associated factors are not well understood.
  • This study investigates factors influencing AVC progression in older adults.

Purpose of the Study:

  • To identify clinical factors and serum biomarkers associated with aortic valve calcification progression.
  • To analyze AVC progression in a population-based cohort of elderly individuals.

Main Methods:

  • Utilized data from the Cardiovascular Abnormalities and Brain Lesion (CABL) and Subclinical Atrial Fibrillation And Risk of Ischemic Stroke (SAFARIS) studies.
  • Assessed AVC severity using a 0-3 grading scale on echocardiography at baseline and follow-up.
  • Measured serum biomarkers, including transforming growth factor beta 1 (TGF-β1), at follow-up.

Main Results:

  • 373 participants (mean age 68.1 years) were analyzed; 37% showed AVC progression.
  • Anti-hypertensive medication use was the sole clinical predictor of any AVC progression.
  • Transforming growth factor beta 1 (TGF-β1) was significantly associated with both all and moderate-severe AVC progression.

Conclusions:

  • A notable proportion of elderly individuals with AVC experience disease progression.
  • Individual vascular risk factors were not significantly associated with AVC progression, suggesting a potential combined effect.
  • Elevated TGF-β1 levels are linked to AVC progression in this cohort.
Abstract

Keywords:
Aortic valve calcificationEchocardiographyTransforming growth factor β1

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