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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

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[A guide to psychiatric prescribing in pregnancy, postpartum and breastfeeding]

H Bottemanne1, L Joly2, H Javelot3

  • 1Department of psychiatry, Pitié-Salpêtrière hospital, DMU Neuroscience, Sorbonne university, Assistance Publique-hôpitaux de Paris (AP-HP), Paris, France; Paris Brain Institute - institut du Cerveau, Inserm, CNRS, Sorbonne university, Paris, France; Sorbonne university, department of philosophy, SND Research Unit, UMR 8011, CNRS, Paris, France.

L'Encephale
|April 8, 2023
PubMed

Insights

This guide offers evidence-based recommendations for perinatal psychopharmacology, addressing the challenges of managing psychiatric disorders during pregnancy and postpartum to improve maternal and infant mental health.

Area of Science:

  • Perinatal Psychiatry
  • Psychopharmacology
  • Maternal-Child Health

Context:

  • Psychiatric disorder management during the perinatal period presents unique challenges due to significant physiological and psychological changes.
  • Perinatal psychopharmacology is an emerging field with evolving considerations regarding psychotropic medication safety for mother and infant.
  • Inadequate management of perinatal mental health poses substantial risks to both maternal and infant well-being.

Purpose:

  • To develop a perinatal psychopharmacology prescription guide.
  • To synthesize available scientific evidence and clinical recommendations.
  • To provide clinicians with a structured decision-making process for prescribing psychotropic medications during pregnancy and postpartum.

Summary:

  • The guide proposes a heuristic-based decision-making process for prescribing psychotropic drugs in the perinatal period.
  • It is grounded in current scientific evidence and international/national guidelines.
  • The aim is to support clinicians in navigating the complexities of perinatal mental healthcare.

Impact:

  • Enhance the quality of perinatal mental healthcare.
  • Mitigate risks associated with untreated or undertreated maternal psychiatric disorders.
  • Improve outcomes for both mothers and infants through informed psychotropic drug management.

Keywords:
AllaitementBreastfeedingGrossesseNeonatologyNéonatologiePerinatalPost-partumPregnancyPsychopharmacologiePsychopharmacologyPérinatal

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