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Updated: Aug 3, 2025
06:24
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
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KLF4 transcription factor in tumorigenesis
Zhihong He1,2, Jie He3, Keping Xie4,5
1Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, China.
Cell Death Discovery
|April 8, 2023
Summary
Krüppel-like factor 4 (KLF4) is crucial for embryonic development and plays a complex role in various cancers. This review explores KLF4
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Krüppel-like transcriptional factors are essential for cellular functions and embryonic development.
- KLF4, a key member, influences embryonic development, skin permeability, and postnatal survival.
- KLF4 is implicated in inflammation and tumorigenesis across multiple cancer types.
Purpose of the Study:
- To review the structural and functional aspects of KLF4.
- To focus on KLF4's role as a clinical biomarker in various tumors.
- To explore KLF4 as a potential therapeutic target in cancer treatment.
Main Methods:
- Literature review of KLF4's function in development and cancer.
- Analysis of KLF4's dual role in transcriptional activation and repression.
- Examination of KLF4's regulatory interactions with signaling molecules.
Main Results:
- KLF4's deletion causes developmental defects and embryonic lethality.
- KLF4 exhibits a complex, context-dependent role in tumorigenesis.
- KLF4 is involved in lung, breast, prostate, and other cancers.
Conclusions:
- KLF4's unique structure contributes to its multifaceted role in cancer.
- KLF4 presents potential as a biomarker for cancer diagnosis and prognosis.
- Targeting KLF4 may offer novel therapeutic strategies for cancer patients.
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