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Trichophyton indotineae, from epidemiology to therapeutic

Arnaud Jabet1, Anne-Cécile Normand2, Sophie Brun3

  • 1Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Service de Parasitologie-Mycologie, Hôpital La Pitié-Salpêtrière, AP-HP, 75013 Paris, France.

Journal De Mycologie Medicale
|April 9, 2023
PubMed

Insights

Trichophyton indotineae, a fungus causing widespread skin infections, often shows resistance to terbinafine due to gene mutations. This review covers its identification, treatment, and prevention to manage this emerging global health threat.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Trichophyton indotineae is an emerging fungal pathogen causing superficial infections.
  • This species is frequently associated with terbinafine resistance, linked to squalene epoxidase gene mutations.
  • T. indotineae infections are spreading globally, necessitating effective control strategies.

Purpose of the Study:

  • To review the taxonomy, epidemiology, and clinical aspects of T. indotineae.
  • To discuss challenges in species identification and antifungal susceptibility testing.
  • To summarize current treatment and prevention strategies for T. indotineae infections.

Main Methods:

  • Literature review of T. indotineae.
  • Analysis of epidemiological data.
  • Summary of clinical case reports and treatment outcomes.

Main Results:

  • T. indotineae causes chronic or recurrent superficial infections.
  • Terbinafine resistance is common and linked to specific genetic mutations.
  • Itraconazole is a common alternative treatment for resistant cases.

Conclusions:

  • Accurate identification and susceptibility testing are crucial for managing T. indotineae.
  • Understanding the global spread of T. indotineae is vital for public health.
  • Effective treatment and prevention measures are needed to control this emerging dermatophyte.
Keywords:
Antifungal resistanceDermatophytesItraconazoleTerbinafineTrichophyton indotineaeTrichophyton mentagrophytes

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