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Updated: Aug 3, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
Published on: July 5, 2024
[Life-cycle management of polycystic ovary syndrome]
Y Xu1
1Reproductive and Genetic Medical Center of Obstertrics and Gynecology, Peking University First Hospital, Beijing 100034, China.
Abstract:
The pathogenesis of polycystic ovary syndrome (PCOS) is complex. The core features are ovarian hyperandrogenism caused by hypothalamus-pituitary-ovarian (HPO) axis dysfunction and hyperinsulinemia caused by insulin resistance. Common clinical manifestations include menstrual disorder, infertility, hyperandrogenism, polycystic ovarian morphology, etc., which can be accompanied by obesity, insulin resistance, dyslipidemia, and other metabolic abnormalities. They are high-risk factors for type 2 diabetes, cardiovascular diseases, and endometrial cancer. Comprehensive intervention measures are crucial to reduce the occurrence of PCOS and its complications. Early identification, early intervention, and reduction of metabolic dysfunction are important means of PCOS life-cycle management.
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