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Clinical Feature and General Management of Post-Hemorrhagic Hydrocephalus in Premature Infants
1Department of Neurosurgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Insights
Posthemorrhagic hydrocephalus (PHH) is a serious neurological complication in premature infants. This review discusses clinical features, prevention, and management strategies for PHH to improve outcomes.
Area of Science:
- Neonatal Neurology
- Pediatric Neurosurgery
- Perinatal Medicine
Background:
- Survival rates for preterm infants have improved, increasing the incidence of prematurity-related complications.
- Posthemorrhagic hydrocephalus (PHH) is the most common serious neurological complication in premature infants, leading to acute risks and lifelong sequelae.
- Current management strategies for PHH lack consensus despite decades of research.
Purpose of the Study:
- To review the clinical features of PHH in premature infants.
- To discuss general and nonsurgical management for intraventricular hemorrhage (IVH) prevention.
- To outline posthemorrhagic management and intervention timing for PHH.
Main Methods:
- Literature review and discussion of existing clinical data and management approaches.
- Analysis of strategies aimed at reducing intraventricular hemorrhage (IVH) incidence.
- Exploration of therapeutic interventions for established PHH.
Main Results:
- PHH presents significant acute and long-term challenges in premature infants.
- Preventive measures for IVH are crucial but not fully effective.
- Optimal timing and methods for PHH intervention remain subjects of ongoing investigation.
Conclusions:
- PHH remains a critical concern in neonatal care, necessitating further research.
- A multidisciplinary approach is essential for managing PHH in premature infants.
- Establishing clear guidelines for PHH management is a priority for improving infant neurodevelopmental outcomes.
Abstract:
Recently, the survival of the high-risk population of preterm infants has steadily improved, and the severity of prematurity is a growing threat of gestational-age-related fatal conditions. Posthemorrhagic hydrocephalus (PHH) is the most common but serious neurological complication in premature infants, which can have life-threatening consequences during the acute phase in the neonatal period and life-long psychomotor and cognitive sequelae in their later life. Although neonatologists, pediatric neurologists, and pediatric neurosurgeons have investigated a diversified strategy for several decades, a consensus on the best management of PHH in premature infants still must be reached. Several approaches have tried to reduce the incidence of intraventricular hemorrhage (IVH) and mitigate the effect of IVH-related hydrocephalus. This paper reviews and discusses the clinical feature of PHH in premature infants, general/nonsurgical management of prematurity for IVH prevention, and posthemorrhagic management, and how and when to intervene.
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