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New daily persistent headache: A systematic review and meta-analysis.
Sanjay Cheema1,2, Dwij Mehta1,2, Jason Charles Ray3,4,5
1Headache and Facial Pain Group, University College London (UCL) Queen Square Institute of Neurology, London, UK.
Cephalalgia : an International Journal of Headache
|April 10, 2023
Summary
New daily persistent headache often mimics chronic migraine but differs in family history, symptoms, and treatment response. Further research is needed for this distinct headache disorder.
Area of Science:
- Neurology
- Headache Medicine
- Systematic Review & Meta-Analysis
Background:
- New daily persistent headache (NDPH) is a distinct primary headache disorder.
- Understanding its epidemiology, characteristics, and treatment is crucial for patient care.
Approach:
- A systematic review and meta-analysis was conducted.
- Searched major databases (PubMed, EMBASE, Cochrane) up to December 2022.
- Included 46 studies with 2155 participants, assessing risk of bias and using random-effects meta-analysis.
Key Points:
- NDPH shares features with chronic migraine but is less associated with family history and migrainous symptoms.
- Patients with NDPH appear less vulnerable to medication overuse.
- Treatment response to injectable and neuromodulatory therapies may be less favorable in NDPH compared to chronic migraine.
Conclusions:
- NDPH is a recognizable disorder requiring further investigation into its pathophysiology and optimal treatments.
- Current evidence quality is limited, supporting its classification as a distinct entity.
- Further high-quality research is essential to improve understanding and management of NDPH.
