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The impact of COVID-19 on liver injury in various age

Amin Sadeghi Dousari1, Seyed Soheil Hosseininasab2, Fatemeh Sadeghi Dousari3

  • 1Department of Microbiology, Jiroft University of Medical Sciences, Jiroft 7861634204, Iran.

World Journal of Virology
|April 10, 2023
PubMed

Insights

The novel coronavirus (COVID-19) is a global pandemic affecting multiple body systems. This review examines how COVID-19 impacts liver injury across different age groups, highlighting its systemic effects beyond respiratory illness.

Area of Science:

  • Virology
  • Hepatology
  • Public Health

Background:

  • The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has led to a global health crisis.
  • COVID-19, caused by the SARS-CoV-2 virus, is primarily a respiratory illness but also acts as a systemic agent affecting multiple organs.
  • Liver involvement is a recognized complication in COVID-19 patients, with varying degrees of injury observed.

Purpose of the Study:

  • To review the impact of COVID-19 on liver injury.
  • To analyze the effects of SARS-CoV-2 on liver function across different age demographics.

Main Methods:

  • Systematic literature review of studies investigating COVID-19 and liver injury.
  • Analysis of clinical data and research findings on SARS-CoV-2-related liver damage.

Main Results:

  • COVID-19 can cause significant liver injury in patients, irrespective of respiratory severity.
  • Liver dysfunction is a common finding in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
  • The extent of liver injury may vary with age, though comprehensive data across all age groups is still emerging.

Conclusions:

  • COVID-19's systemic nature extends to the liver, causing notable injury.
  • Understanding age-related differences in COVID-19 liver injury is crucial for comprehensive patient management.
  • Further research is needed to fully elucidate the mechanisms and long-term consequences of SARS-CoV-2 on liver health across the lifespan.

Keywords:
Coronavirus disease 2019Liver injuryMinireviewSevere acute respiratory syndrome coronavirus 2

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