Obesity-induced ocular changes in children and adolescents: A review
Julia Dezor-Garus1, Elżbieta Niechciał2, Andrzej Kędzia2
1Department of Ophthalmology, Poznan University of Medical Sciences, Poznan, Poland.
Insights
Childhood obesity may affect eye health, potentially altering retinal microvasculature and nerve fiber layer thickness. More research is needed to confirm these links in children and adolescents.
Area of Science:
- Ophthalmology
- Pediatrics
- Public Health
Background:
- Childhood obesity is a global epidemic linked to inflammation and vascular dysfunction.
- Ocular manifestations of childhood obesity are understudied and findings are inconsistent.
- Existing evidence suggests potential links between obesity and changes in retinal parameters.
Purpose of the Study:
- To review current literature on childhood obesity and its potential ocular effects.
- To synthesize findings from international publications between 1992 and 2022.
- To highlight areas needing further investigation in pediatric obesity and eye health.
Main Methods:
- Systematic review of international publications from 1992-2022.
- Analysis of studies focusing on childhood obesity and ocular parameters.
- Synthesis of evidence regarding retinal microvasculature, intraocular pressure, and retinal nerve fiber layer.
Main Results:
- Obesity is associated with altered retinal microvasculature (wider venules, narrower arterioles, lower arteriovenous ratio).
- Higher intraocular pressure correlates positively with high body mass index (BMI) and obesity.
- Lower retinal nerve fiber layer (RNFL) values observed in obese children, negatively correlating with anthropometric/metabolic parameters.
Conclusions:
- Childhood obesity may contribute to significant ocular changes, including retinal and choroidal thickness variations.
- Associations between obesity and retinal vessel density require further consistent documentation.
- This review underscores the need for continued research into the ocular complications of pediatric obesity.
Abstract:
Childhood obesity has reached epidemic levels worldwide. Overweight and obesity is associated with an increase in several inflammatory markers, leading to chronic low-grade inflammation responsible for macro- and microvascular dysfunction. While the impact of obesity on overall health is well-described, less is known about its ocular manifestations. Still, there are few studies in children and adolescents in this regard and they are inconsistent. However, some evidence suggests a significant role of overnutrition in the development of changes in retinal microvasculature parameters (wider venules, narrower arterioles, lower arteriovenous ratio). Higher values of intraocular pressure were found to be positively correlated with high body mass index (BMI) as well as obesity. In addition, the retinal nerve fiber layer (RNFL) values seem to be lower in obese children, and there is a significant negative correlation between RNFL values and anthropometric and/or metabolic parameters. Changes also could be present in macular retinal thickness and choroidal thickness as well as in the retinal vessel density in children with obesity. However, these associations were not consistently documented. The purpose of this review is to present the most current issues on child obesity and the related potential ocular effects through an overview of international publications from the years 1992-2022.
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