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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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Clinical features of renal damage associated with Epstein-Barr virus infection in children

Xiaoqing Yang1,2, Baohua Lin1,2, Tong Shen1,2

  • 1Pediatrics Department, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.

Frontiers in Pediatrics
|April 10, 2023
PubMed

Insights

Acute Epstein-Barr virus (EBV) infection can cause significant renal damage in children, with symptoms like hematuria and proteinuria. Early detection and monitoring are crucial for managing this common pediatric condition.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Virology

Background:

  • Acute Epstein-Barr virus (EBV) infection is common in children.
  • Renal involvement can be a complication of acute EBV infection.
  • Understanding the clinical features and incidence of renal damage in pediatric EBV is important for patient management.

Purpose of the Study:

  • To investigate the incidence and clinical characteristics of renal damage in pediatric patients with acute Epstein-Barr virus (EBV) infection.
  • To identify factors associated with renal damage in children diagnosed with acute EBV.

Main Methods:

  • A retrospective observational study was conducted on 548 pediatric patients diagnosed with acute EBV infection.
  • Patients were divided into groups based on the presence or absence of renal damage.
  • Sociodemographic and clinical data were collected and analyzed for comparison between groups.

Main Results:

  • The incidence of renal damage in pediatric patients with acute EBV infection was 7.48% (41 out of 548).
  • Common renal manifestations included hematuria, proteinuria, edema, and hypertension; acute renal failure was observed in 2.44% of affected patients.
  • Patients with renal damage experienced longer fever durations, higher EBV-DNA loads, and lower CD4+/CD8+ T lymphocyte ratios compared to those without renal damage.

Conclusions:

  • Acute EBV infection can lead to a notable rate of renal damage in pediatric patients.
  • Hematuria and proteinuria are the most frequent clinical signs of renal involvement.
  • Prolonged fever, high EBV-DNA load, and decreased CD4+/CD8+ ratios indicate a higher risk of secondary renal damage.
Abstract

Keywords:
Epstein-Barr viruschildrenhematuriainfectious mononucleosisrenal damage

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