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The Spectrum of MRI and Electrographic Findings in Pediatric Patients With Seizures: A Retrospective Tertiary Care
Reem A Alyoubi1,2, Razan K Daghistani3, Afaf M Albogmi4,5
1Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, SAU.
Insights
Pediatric seizures are common, with focal seizures being most frequent. Brain Magnetic Resonance Imaging (MRI) reveals developmental anomalies as the primary abnormality in children experiencing seizures.
Area of Science:
- Pediatric neurology
- Neuroradiology
Background:
- Seizures are a significant public health issue in pediatric populations.
- Magnetic Resonance Imaging (MRI) is crucial for assessing brain abnormalities in children.
Purpose of the Study:
- To investigate clinical findings in pediatric patients with seizures.
- To correlate seizure types with Magnetic Resonance Imaging (MRI) findings.
Main Methods:
- Retrospective cohort study (2021-2022) at King Abdulaziz University Hospital.
- Included 171 pediatric patients (ages 1-14) with seizures who underwent brain MRI.
- Mean age of participants was two years.
Main Results:
- Focal seizures (60.2%) were more common than generalized seizures.
- Developmental anomalies were the most frequent MRI finding (18.5%).
- Other findings included hypoxic-ischemic injury, vascular abnormalities, metabolic disorders, and infections.
Conclusions:
- MRI plays a vital role in diagnosing pediatric seizures and improving patient prognosis.
- Accurate diagnosis through MRI is essential for effective patient care.
- Electroencephalogram (EEG) should be considered in standard neurodiagnostic testing alongside MRI.
Abstract:
Background Seizures constitute a serious public health concern, especially in pediatric patients. They are among the most prevalent medical issues affecting children. Magnetic resonance imaging (MRI) is a widely used imaging modality to evaluate, assess, and follow up on brain abnormalities. Objectives The purpose of the study is to explore the clinical findings of pediatric patients with seizures and their associated findings on MRI examinations. Material and methods A retrospective cohort study was conducted between 2021 and 2022 at King Abdulaziz University Hospital (KAUH). A total of 171 pediatric patients (ages 1-14 years old) who had seizures and underwent brain MRI examinations were included in the study. The mean age of the group was two years. Results Focal seizures represented the majority of seizure types in 62 (60.2%) patients compared to 42 patients who presented with generalized seizures and 67 patients who presented with normal findings based on magnetic resonance imaging (MRI) analysis. The most common finding in imaging was the presence of developmental anomalies, which were found in 31 (18.5%) patients. This was followed by hypoxic-ischemic injury in 12 patients, vascular abnormalities in 10 patients, inherited metabolic disorders in nine patients, and infection-related findings in six patients. Conclusion MRI has an invaluable role in managing pediatric patients with seizures. Accurate diagnosis of patients is an essential step for delivering proper care to patients. MRI is considered the main imaging modality to establish a correct diagnosis and thereby improve prognosis, and electroencephalogram (EEG) should be taken into account during standard neurodiagnostic testing.
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