Related Experiment Video
Updated: Aug 3, 2025
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
9.0K
Lipid-engineered nanotherapeutics for cancer management
Alicia Fernandez-Fernandez1, Romila Manchanda2, Manisha Kumari2
1College of Healthcare Sciences, Nova Southeastern University, Fort Lauderdale, FL, United States.
Frontiers in Pharmacology
|April 10, 2023
Summary
Lipid-engineered nanotherapeutics offer improved cancer treatment by overcoming drug delivery barriers. These advanced systems enhance targeted delivery, reduce toxicity, and improve efficacy for better patient outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer treatment faces limitations due to disease heterogeneity and drug delivery challenges.
- Conventional therapies suffer from poor efficacy, specificity, and significant side effects.
- Nanotherapeutics offer a promising avenue to overcome these limitations through rational design.
Purpose of the Study:
- To review the diverse formulations of lipid-engineered nanotherapeutics for cancer treatment.
- To highlight advances in nano-sized delivery systems and surface engineering for targeted drug delivery.
- To discuss current challenges in translating these nanotherapeutic approaches to clinical practice.
Main Methods:
- Exploration of lipid-based nanosystems, including liposomes, nanoemulsions, and solid lipid nanoparticles.
- Analysis of surface engineering strategies for customized drug delivery.
- Review of literature on nanotherapeutics overcoming pharmacokinetic and biodistribution challenges.
Main Results:
- Lipid-based nanotherapeutics demonstrate high biocompatibility, versatility, and adaptability.
- These systems show potential for targeted, site-specific drug delivery, minimizing off-target effects.
- Nanotherapeutics can improve drug solubility, permeability, and overall therapeutic efficacy.
Conclusions:
- Lipid-engineered nanotherapeutics represent a significant advancement in cancer therapy.
- Further research and clinical translation are crucial to realize the full potential of these novel drug delivery systems.
- Overcoming existing challenges will pave the way for more effective and safer cancer treatments.
Related Concept Videos
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K