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Therapeutic potential of TRPM8 channels in cancer treatment

Sara V Ochoa1,2, Zulma Casas1, Sonia L Albarracín1

  • 1Departamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, Colombia.

Frontiers in Pharmacology
|April 10, 2023
PubMed

Insights

The transient receptor potential melastatin 8 (TRPM8) channel plays a key role in various cancers. Targeting TRPM8 offers potential therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Channelopathies

Background:

  • Cancer involves altered signaling pathways affecting cell cycle and gene expression.
  • Transient receptor potential melastatin 8 (TRPM8) channels are involved in thermosensation, differentiation, and migration.
  • TRPM8 channels are implicated in physiological processes relevant to cancer, including proliferation, survival, and invasion.

Purpose of the Study:

  • To review the current understanding of TRPM8 channel roles in cancer progression.
  • To explore the therapeutic potential of TRPM8 as a molecular target in carcinogenesis.

Main Methods:

  • Literature review of studies on TRPM8 channels in various cancer types.
  • Analysis of TRPM8's involvement in cancer-related physiological processes.
  • Evaluation of TRPM8 as a therapeutic target in oncology.

Main Results:

  • TRPM8 channels are crucial in prostate cancer diagnosis, prognosis, and treatment.
  • TRPM8 involvement is reported in pancreatic, breast, bladder, colon, gastric, skin cancers, glioblastoma, and neuroblastoma.
  • TRPM8 channels influence cancer cell proliferation, survival, and invasion.

Conclusions:

  • TRPM8 channels are significantly involved in the progression of multiple cancer types.
  • Targeting TRPM8 presents a promising therapeutic avenue for cancer treatment.
  • Further research into TRPM8's role could lead to novel anticancer strategies.
Keywords:
TRPM8TRPM8 pharmacologycancermolecular targetsignaling pathway

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