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Dose optimization of vancomycin in obese patients: A systematic review
Mahmoud E Elrggal1, Abdul Haseeb1, Manal AlGethamy2
1Department of Clinical Pharmacy, College of Pharmacy, Umm AL-Qura University, Makkah, Saudi Arabia.
Frontiers in Pharmacology
|April 10, 2023
Summary
Optimizing vancomycin dosing in obese patients is crucial due to altered pharmacokinetics. Current strategies suggest loading and maintenance doses for adults and specific daily doses for pediatrics, but further research is needed.
Area of Science:
- Pharmacokinetics
- Infectious Diseases
- Clinical Pharmacy
Background:
- Obesity prevalence impacts vancomycin pharmacokinetics, necessitating optimized dosing strategies.
- Current vancomycin dosing in obese populations requires systematic review to ensure efficacy and safety.
Conclusions:
- Total body weight (TBW) may predict vancomycin trough concentration but clinical significance is uncertain.
- Further research is essential to refine vancomycin dosing strategies for overweight and obese individuals.
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