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Updated: Aug 3, 2025
Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Human Amylin in the Presence of SARS-COV-2 Protein Fragments
Andrew D Chesney1, Buddhadev Maiti1, Ulrich H E Hansmann1
1Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Abstract:
COVID-19 can lead to the onset of type-II diabetes, which is associated with the aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium between amylin monomers in its functional form and fibrils associated with diabetes is altered in the presence of SARS-COV-2 protein fragments. For this purpose, we study the interaction between the fragment SFYVYSRVK of the envelope protein or the fragment FKNIDGYFKI of the spike protein with the monomer and two amylin fibril models. Our results are compared with earlier work studying such interactions for the two different proteins.
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