Related Experiment Video
Updated: Aug 3, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
An updated review of the immunological mechanisms of keloid scars
Chih-Chun Lee1, Chia-Hsuan Tsai2,3, Chih-Hao Chen2,3
11 Department of Medical Education, Chang Gung Memorial Hospital, Keelung, Taiwan.
Abstract:
Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics.
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