Related Experiment Video

Updated: Aug 3, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

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FSBP suppresses tumor cell migration by inhibiting the JNK pathway

Fangyu Song1, Wenshuo Zhang1,2, Xiaohui Li1

  • 1College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.

Iscience
|April 10, 2023
PubMed

Insights

This study identifies Apt/FSBP as a tumor suppressor. Loss of Apt/FSBP promotes cancer cell migration and metastasis, highlighting its potential as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Tumor metastasis is a primary cause of cancer mortality.
  • Understanding metastasis mechanisms is crucial for effective clinical treatments.

Purpose of the Study:

  • To identify novel regulators of tumor metastasis.
  • To investigate the role of Apt/FSBP in tumor suppression and metastasis.

Main Methods:

  • Utilized *Drosophila* wing disc models to study Apt function.
  • Generated liver-specific *Fsbp* knockout mice for in vivo studies.
  • Investigated the effect of Apt/FSBP on cell migration and JNK pathway activation.

Main Results:

  • Knockdown of *apt* in *Drosophila* induced cell migration.
  • Overexpression of *apt* inhibited *scrib*-RNAi-induced migration.
  • Loss of *Fsbp* in mice promoted liver tumorigenesis and accelerated metastasis.
  • Apt/FSBP loss activates the JNK pathway, promoting cell migration.

Conclusions:

  • Apt/FSBP acts as a tumor suppressor, inhibiting metastasis.
  • FSBP is a potential therapeutic target for combating cancer metastasis.
Keywords:
CancerCell biologyCellular physiology

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