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Nano-enabled agglomerates and compact: Design aspects of challenges
Nazurah Binti Sazali1, Lai Wah Chan1, Tin Wui Wong1,2,3
1Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore.
Asian Journal of Pharmaceutical Sciences
|April 10, 2023
Summary
Nanoparticle processing into microscale dosage forms can alter their properties. This review identifies risks and strategies to maintain nanoparticle integrity during agglomeration and compaction for effective nanomedicine delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Nanomedicine offers targeting advantages but faces processing challenges like nanoparticle aggregation.
- Aggregation leads to poor yield, flowability, and inefficient drug administration, necessitating conversion to microscale dosage forms.
Purpose of the Study:
- To review risk factors during nanoparticle agglomeration and compaction that can alter nanomedicine properties.
- To discuss strategies for maintaining nanoparticle physicochemical and biological integrity during processing.
Main Methods:
- Literature review of nanoparticle processing techniques (agglomeration, compaction).
- Analysis of risk factors including material selection, temperature, physical forces, and environmental stresses.
- Identification of modulation strategies for material-process-environment interactions.
Main Results:
- Agglomeration and compaction can compromise nanoparticle nanogeometry, surface chemistry, and biological performance.
- Key risk factors involve the interplay between material properties and processing conditions.
- Strategies exist to mitigate these risks by controlling processing variables.
Conclusions:
- Careful consideration of material choice and processing parameters is crucial for successful nanomedicine formulation.
- Maintaining nanoparticle integrity during scale-up is essential for realizing nanomedicine's therapeutic potential.
- Modulating process-material interactions can preserve nanomedicine efficacy.
