EDTA-induced pseudothrombocytopenia in hematopoietic stem cell donor
Misato Tsubokura1, Minoru Kojima2, Saori Nakabayashi1
1Department of Laboratory Medicine National Cancer Center Hospital Tokyo Japan.
Peripheral blood stem cell transplantation (PBSCT) was performed using a donor with EDTA-induced pseudothrombocytopenia (PTCP). No platelet clumping or PTCP symptoms were observed in the recipient post-transplant.
Area of Science:
- Hematology
- Transplantation Immunology
Background:
- EDTA-induced pseudothrombocytopenia (PTCP) is a laboratory artifact that can complicate blood product management.
- Peripheral blood stem cell transplantation (PBSCT) involves collecting and infusing hematopoietic stem cells.
Observation:
- A case involving peripheral blood stem cell transplantation (PBSCT) from a donor with confirmed EDTA-induced PTCP is presented.
- The apheresis product was monitored for 24 hours, showing no evidence of platelet clumping or thrombocytopenia.
Findings:
- The peripheral blood stem cell transplantation procedure was successfully completed without complications related to the donor's PTCP.
- Post-transplantation monitoring for 14 months revealed no signs or symptoms of PTCP transfer to the recipient.
Implications:
- This case suggests that PBSCT from donors with EDTA-induced PTCP is feasible and safe.
- It highlights the importance of differentiating artifactual PTCP from true thrombocytopenia in stem cell donors.
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