Development and Evaluation of Silver Nanomix as a Next-Generation Tool for Wound Healing and Dressing Applications

This investigation reports silver nanomix as a next-generation, cost-effective, and clinically translatable nanomaterial tool for wound healing and dressing applications. Silver nanomix was developed by systematically hybridizing silver nanoparticles (AgNPs; sub-15 nm; Design Expert tool) with ionic Ag. The silver nanomix elicited significantly higher antibacterial potential than conventional silver products and marketed reference antibiotics, as studied in Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Furthermore, the biomechanics of action, safety profile, and intracellular silver organization by silver nanomix are also studied exhaustively. This research presents a viewpoint and direction in designing silver-based antimicrobial dressings with a 40% reduction in their cost.