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CoVe-Tracker: An Interactive SARS-CoV-2 Pan Proteome Evolution Tracker
Chakkarai Sathyaseelan1, Murali Aadhitya Magateshvaren Saras1, L Ponoop Prasad Patro1
1Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana State 502285, India.
Journal of Proteome Research
|April 10, 2023
Summary
The CoVe-tracker platform monitors SARS-CoV-2 evolution, tracking mutations and variants globally. This tool aids in understanding viral spread and developing effective public health strategies against evolving viruses.
Area of Science:
- Virology
- Genomics
- Epidemiology
Background:
- SARS-CoV-2 continuously mutates, leading to variants with altered transmissibility and immune evasion.
- Tracking viral evolution is crucial for public health interventions and vaccine development.
Purpose of the Study:
- To develop an interactive platform, CoVe-tracker, for monitoring SARS-CoV-2 evolutionary dynamics.
- To provide users with country-wise and protein-wise mutation data, alongside lineage tracking.
Main Methods:
- Development of a web-GUI platform (CoVe-tracker) for visualizing SARS-CoV-2 genomic evolution.
- Integration of mutation data, PANGO lineages, and variant information with geographical and temporal distributions.
- Utilizing interactive visualizations including world maps and protein 3D structures.
Main Results:
- CoVe-tracker offers access to 44,139 amino acid mutations and 177,564 variants across 2,065 PANGO lineages.
- The platform visualizes mutation and lineage distributions by country and month.
- Demonstrated utility in tracking related variants, using BA.4 and BA.5 as examples.
Conclusions:
- CoVe-tracker facilitates rapid surveillance of emerging SARS-CoV-2 mutations and variants.
- The platform aids in understanding viral evolution, transmission dynamics, and disease epidemiology.
- CoVe-tracker is a valuable resource for researchers and public health officials monitoring the pandemic.
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