Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Anxiety: Overview

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Panic Disorder

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...

Social Anxiety Disorder

Social Anxiety Disorder

Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular basis of CXC chemokine receptor 3 ligand multispecificity.

Science advances·2026

Same author

Lymphadenopathy: Evaluation and Differential Diagnosis.

American family physician·2025

Same author

Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using near-infrared spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measures design in patients with breast and gynecological cancer.

PloS one·2025

Same author

A Case of Necrotizing Lymphadenitis From Streptococcus pyogenes.

Cureus·2025

Same author

Frontal damage and resolution of schizophrenia in a patient with self-inflicted gunshot wound: a case report.

BMC neurology·2025

Same author

Impact of Time in Therapeutic Range on Adverse Events in Atrial Fibrillation Patients in an Ambulatory Care Setting.

Hospital pharmacy·2024

Search research articles

Related Experiment Video

Updated: Aug 3, 2025

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Mood and Anxiety Disorders: Suicide.

Ashley Wilk¹, Ashley Falk¹, Rosa Joseph¹

¹Department of Family Medicine and Rural Health - Florida State University College of Medicine, 1115 West Call St, Tallahassee, FL 32306.

|April 10, 2023

Summary

Suicide prevention requires understanding risk factors like isolation and mental health conditions. Physicians should directly assess suicide plans, as questioning does not increase risk, and manage comorbid mood disorders.

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Aug 3, 2025

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

Area of Science:

Public Health
Psychiatry
Clinical Medicine

Background:

Suicide caused over 47,500 deaths in the US in 2019.
Females attempt suicide more often, but males have higher completed suicide rates.
Older adults (over 75) and individuals with mental disorders face elevated suicide risks.

Purpose of the Study:

To summarize key aspects of suicide risk, assessment, and management.
To highlight pharmacotherapy options for major depressive disorder (MDD) with suicidal ideation.
To emphasize the importance of comprehensive suicide risk assessment over "no harm" contracts.

Main Methods:

Review of epidemiological data on suicide demographics and risk factors.
Discussion of clinical guidelines for suicide risk assessment.
Overview of pharmacotherapeutic strategies for managing suicidality, including MDD.

Main Results:

Increased suicide risk is associated with isolation, poverty, and mental health conditions like MDD.
Direct questioning about suicide plans is safe and essential for risk assessment.
Esketamine nasal spray is an approved pharmacotherapy for MDD with acute suicidal ideation/behavior.

Conclusions:

Effective suicide prevention involves identifying risk factors and performing thorough clinical evaluations.
Pharmacotherapy should target comorbid mood disorders, particularly MDD.
Clinical judgment and formal risk assessment are crucial, not solely relying on "no harm" agreements.