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A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Return emergency department visits for recurrent pulmonary embolism symptoms in children and adolescents
Dana Egan-Sherry1, Philip Grosse2, James D Cooper1
1Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplant, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Insights
Pulmonary embolism (PE) in children often leads to return visits for related symptoms, with increased age and female sex as risk factors. Recurrence is rare when patients maintain appropriate anticoagulation.
Area of Science:
- Pediatric Medicine
- Cardiology
- Radiology
Background:
- Pediatric pulmonary embolism (PE) rates have risen significantly over 20 years.
- Outcomes post-hospitalization for pediatric PE are not well-understood.
- Many children experience persistent symptoms like chest pain or dyspnea after PE diagnosis.
Purpose of the Study:
- To assess emergency department (ED) return rates for PE-related symptoms in children.
- To evaluate the diagnostic utility of repeat computed tomography angiography (CTA) in pediatric PE patients.
- To identify risk factors for ED return visits and PE recurrence.
Main Methods:
- Retrospective cohort study of 96 pediatric patients diagnosed with PE.
- Analysis of return visits to the ED for PE-related symptoms.
- Review of repeat computed tomography angiography (CTA) utilization and outcomes.
Main Results:
- 42% of patients returned to the ED for PE-related symptoms, with a median return time of 34 days.
- Repeat CTAs were frequently performed (74 total), averaging 1.8 per returning patient.
- Increased age and female sex were identified as risk factors for ED return visits; PE recurrence was 8% and linked to thrombotic risk factors.
Conclusions:
- Pediatric PE patients frequently return to the ED for related symptoms, often necessitating repeat imaging.
- Risk factors for return visits include older age and female sex.
- Developing risk stratification for PE recurrence can help optimize follow-up care and reduce unnecessary imaging.
Abstract:
Rates of pulmonary embolism (PE) in children have steadily increased over the past 2 decades. Patient outcomes after hospital discharge are poorly understood, and many patients experience recurrent or persistent chest pain or dyspnea, prompting a return to care. This retrospective cohort study of patients diagnosed with PE at a large children's hospital over a 9.5-year period was performed to evaluate rates of return to the emergency department (ED) for PE-related symptoms, and to determine the utility of repeat computed tomography angiography (CTA) in this population. Ninety-six patients were diagnosed with PE during the study period. Forty-two percent of patients (n = 40) returned to the ED for PE-related symptoms and a total of 74 repeat CTAs were performed. Among those who had return visits, the mean number of return visits was 3 and the mean number of repeat CTAs was 1.8. The median time to return to the ED was 34 days. Logistic regression analysis identified increased age and female sex as risk factors for return ED visits. Eight percent of the cohort experienced PE recurrence. Recurrent PE was observed only in those with persistent or new thrombotic risk factors and was uncommon in those who remained on appropriate anticoagulation. Future work should focus on the development of a risk stratification system to identify patients at low risk of recurrence in order to minimize repeat CTA imaging.
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