Related Experiment Video For Fluorescence imaging
Updated: Aug 3, 2025
Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
Published on: May 8, 2017
Hypochlorous acid-activated near-infrared fluorescent probe for in vivo/exogenous detection and dairy toxicity
Xiao Wang1, Xuechuan Wang2, Qiangqiang Lu3
1College of Chemistry and Chemical Engineering, Shaanxi University of Science &Technology, Xi'an 710021, PR China.
Abstract:
Oxidative stress has been reported to be closely associated with many diseases, and an excessive overdose of hypochlorite (ClO-) can also induce stress-related diseases. In this study, we designed and synthesized a NIR probe, named W-1a based on computational analysis of DCM (4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran) derivatives for specific detection of ClO-. The probe exhibited dual fluorescence and colorimetric sensing with a response time of <1 min and a detection limit of 0.15 μM. Additionally, the probe was successfully applied for fluorescence imaging of ClO- at the cellular level and ebrafish endogenous/exogenous ClO- assay and dairy toxicity assessment. Thus, we present a potential method for developing an efficient and reliable detection of ClO- in early stage using near-infrared dyes.
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