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Published on: May 5, 2022
Causes of Childhood Blindness in the United States Using the IRIS® Registry (Intelligent Research in Sight)
Han Woong Lim1, Suzann Pershing2, Darius M Moshfeghi3
1Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California; Department of Ophthalmology, Hanyang University School of Medicine, Seoul, Republic of Korea.
Purpose:
To investigate causes of childhood blindness in the United States using the IRIS® Registry (Intelligent Research in Sight).
Design:
Cross-sectional study.
Participants:
Patients ≤ 18 years of age with visual acuity (VA) 20/200 or worse in their better-seeing eye in the IRIS Registry during 2018.
Methods:
Causes of blindness were classified by anatomic site and specific diagnoses.
Main Outcome Measures:
Percentages of causes of blindness.
Results:
Of 81 164 children with 2018 VA data in the IRIS Registry, 961 (1.18%) had VA 20/200 or worse in their better-seeing eye. Leading causes of blindness were retinopathy of prematurity (ROP) in 301 patients (31.3%), nystagmus in 78 patients (8.1%), and cataract in 64 patients (6.7%). The retina was the leading anatomic site (47.7%) followed by optic nerve (11.6%) and lens (10.0%). A total of 52.4% of patients had treatable causes of blindness.
Conclusions:
This analysis offers a unique cross-sectional view of childhood blindness in the United States using a clinical data registry. More than one-half of blind patients had a treatable cause of blindness.
Financial Disclosure(S):
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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