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Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Novel therapeutics in rare genetic obesities: A narrative review
Beatrice Dubern1, Nathan Faccioli1, Christine Poitou2
1Assistance Publique Hôpitaux de Paris, Trousseau Hospital, Pediatric Nutrition and Gastroenterology Department, French Reference Center for Prader-Willi Syndrome and other rare obesities (PRADORT), Paris, France; Systemic approaches, NutriOmics research group, 75013 Paris, France; Sorbonne Université, INSERM, Nutrition and obesities, NutriOmics research group, 75013 Paris, France.
Abstract:
The better understanding of the molecular causes of rare genetic obesities and its associated phenotype involving the hypothalamus allows today to consider innovative therapeutics focused on hunger control. Several new pharmacological molecules benefit patients with monogenic or syndromic obesity. They are likely to be among the treatment options for these patients in the coming years, helping clinicians and patients prevent rapid weight progression and eventually limit bariatric surgery procedures, which is less effective in these patients. Their positioning in the management of such patients will be needed to be well defined to develop precision medicine in genetic forms of obesity.
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