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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Altered brain structural and functional connectivity in cannabis users.

Najme Soleimani1, Kamran Kazemi2, Mohammad Sadegh Helfroush1

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Summary
This summary is machine-generated.

This study found that cannabis use alters local brain network connectivity in young adults, particularly in specific cortical regions. While global brain network organization remains intact, local network changes are linked to cannabis use duration.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Brain Connectivity

Background:

  • Cannabis is a widely used substance, particularly among young adults.
  • The neurobiological effects of cannabis, especially in adolescent and young adult brains, require further investigation.
  • Understanding brain structural and functional alterations associated with cannabis use is crucial.

Purpose of the Study:

  • To investigate alterations in brain structural and functional connectivity in cannabis users compared to healthy controls.
  • To examine the relationship between cannabis use duration and brain network properties.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion-weighted imaging (DWI).
  • Analyzed data from 73 cannabis users and 73 healthy controls from the Human Connectome Project (HCP).
  • Assessed local and global network measures, including rich-club organization and small-world properties.

Main Results:

  • Observed significant differences in local structural and functional network measures (e.g., degree, clustering coefficient) in cannabis users, notably in the insular, frontal opercular, and temporal cortex.
  • Found minor differences in structural and functional rich-club organization between groups, primarily in temporal and parietal regions.
  • Identified associations between regional network measures and times used cannabis (TUC), with a significant link between degree and TUC in the presubiculum after correction.

Conclusions:

  • Cannabis use is associated with alterations in the local topological properties of brain structural and functional networks.
  • Global brain network organization and small-world properties remain largely intact in cannabis users.
  • Local network alterations may be influenced by the duration of cannabis use.