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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Related Experiment Video

Updated: Aug 3, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Vitamin D and SARS-CoV-2.

Sofie-Louise Feentved Ødum1, Martin Kongsbak-Wismann1

  • 1The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Basic & Clinical Pharmacology & Toxicology
|April 10, 2023
PubMed
Summary
This summary is machine-generated.

Vitamin D supplementation may not prevent severe COVID-19, but it might help manage the cytokine storm in patients with severe disease. Further research into the vitamin D receptor (VDR) is needed.

Keywords:
COVID-19HVDRRSARS-CoV-2Vitamin DVitamin D receptor

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Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to global health challenges.
  • The role of vitamin D in mitigating COVID-19 severity remains controversial, with conflicting study results.
  • Investigating the vitamin D receptor (VDR) may clarify discrepancies in vitamin D's effect on COVID-19.

Purpose of the Study:

  • To explore the molecular mechanisms of vitamin D receptor (VDR) in regulating the immune response to SARS-CoV-2.
  • To reconcile conflicting findings regarding vitamin D's impact on COVID-19 disease severity and mortality.

Main Methods:

  • Review and analysis of recent molecular studies focusing on VDR transcriptional regulation.
  • Examination of immune responses in COVID-19 patients with varying vitamin D levels and VDR function.

Main Results:

  • Severe COVID-19 patients' cells showed a dysregulated vitamin D response.
  • A patient with a non-functional VDR exhibited a normal immune response to SARS-CoV-2.
  • Hypovitaminosis D is not essential for an effective immune response against SARS-CoV-2.

Conclusions:

  • Vitamin D deficiency is not a prerequisite for severe COVID-19.
  • Vitamin D may offer benefits in severe COVID-19 cases, potentially by mitigating the cytokine storm.
  • Further molecular investigation of VDR is crucial for understanding vitamin D's role in COVID-19.