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Anomalous glucose-responsive rheological changes in a boronic acid-modified hyaluronan
Ryotaro Miki1, Tsutomu Yamaki1, Masaki Uchida1
1Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. rmiki@josai.ac.jp.
Abstract:
Herein, we report anomalous glucose (Glc)-responsive gelation/solation in 3-aminophenylboronic acid-modified hyaluronic acid. With 5-20 mM Glc, gelation occurred, resulting in the formation of crosslinks via Glc, which could reversibly bind to the two boronic acid sites. Solation was induced at Glc concentrations of >80 mM.
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