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Related Concept Videos

Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Extracellular Matrix01:42

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Overview
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Elastin is Responsible for Tissue Elasticity01:12

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Connective Tissue Fibers and Ground Substance01:17

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One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
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Related Experiment Video

Updated: Aug 3, 2025

Author Spotlight: Dissection and Isolation of Region-Specific Decellularized Lung Tissue
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Author Spotlight: Dissection and Isolation of Region-Specific Decellularized Lung Tissue

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Age-associated differences in the human lung extracellular matrix.

Maunick Lefin Koloko Ngassie1,2, Maaike De Vries2,3, Theo Borghuis1

  • 1Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|April 11, 2023
PubMed
Summary
This summary is machine-generated.

Aging human lungs show increased extracellular matrix (ECM) remodeling, with seven specific ECM proteins elevated in both gene and protein levels. These age-associated ECM changes occur in distinct lung regions, potentially impacting lung function and disease susceptibility.

Keywords:
agingairway wallextracellular matrixlungparenchyma

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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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Area of Science:

  • Pulmonary Medicine
  • Aging Research
  • Biochemistry

Background:

  • Extracellular matrix (ECM) remodeling is linked to chronic lung diseases.
  • Limited data exists on age-specific changes in lung ECM composition and localization.

Purpose of the Study:

  • To identify and localize age-associated differences in the human lung ECM.
  • To investigate the impact of aging on ECM proteins using multi-omics approaches.

Main Methods:

  • Re-analysis of transcriptomic data focusing on Matrisome core genes in 270 control lungs.
  • Validation of age-associated ECM genes with proteomic data from 9 control lungs.
  • Immunohistochemical analysis of lung tissues from 62 control individuals (18-82 years).

Main Results:

  • Seven ECM proteins (COL1A1, COL6A1, COL6A2, COL14A1, FBLN2, LTBP4, LUM) showed increased gene and protein levels with age.
  • COL6A2 levels increased with age in whole tissue, parenchyma, airway wall, and blood vessels.
  • COL14A1 and LUM increased in bronchial epithelium; COL1A1 increased in lung parenchyma with age.

Conclusions:

  • Aging is associated with significant lung ECM remodeling, with regional variations in protein expression.
  • These age-related ECM alterations may influence lung structure, physiology, and susceptibility to chronic lung diseases.