Related Experiment Video
Updated: Aug 3, 2025
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
14.4K
Neonatal Lymphatic Flow Disorder.
Handan Hakyemez Toptan1, Elif Ozalkaya2, Nilgun Karadag2
1Department of Neonatology, University of Health Sciences, Zeynep Kamil Maternity and Children's Disease Health Training and Research Center, Istanbul, Turkey. mdhandanhakyemez@gmail.com.
Indian Journal of Pediatrics
|April 11, 2023
Summary
Congenital chylothorax in newborns often requires a multidisciplinary approach including medication and dietary changes. Ocreotide and medium-chain triglycerides (MCT) showed positive treatment responses in infants.
Area of Science:
- Neonatal Medicine
- Pediatric Cardiology
- Thoracic Surgery
Background:
- Neonatal chylothorax, characterized by lymphatic fluid in the pleural space, presents diagnostic and therapeutic challenges.
- Both congenital and acquired forms occur, with congenital types being more prevalent in the neonatal period.
Purpose of the Study:
- To review and discuss neonatal chylothorax cases, analyzing congenital versus acquired etiologies.
- To evaluate treatment strategies and outcomes, including medication and dietary interventions.
Main Methods:
- Retrospective review of neonatal intensive care unit (NICU) patient records with chylothorax diagnosis.
- Classification of patients into isolated chylothorax (Group 1) and those with multiple lymphatic disorders (Group 2).
- Comparison of antenatal and clinical features, and treatment responses between groups.
Main Results:
- Congenital chylothorax accounted for 92.3% of the 13 diagnosed infants; 61.5% had antenatal diagnosis and 61.5% presented with hydrops fetalis.
- Ocreotide treatment and sepsis incidence showed partial significance (p=0.05) between groups.
- Medium-chain triglycerides (MCT) led to response in 66.6% and complete resolution in 85.7% of responders. Ocreotide achieved complete resolution in 77.7% of responders.
Conclusions:
- Neonatal chylothorax management necessitates a multidisciplinary approach.
- Key interventions include drug therapy (e.g., ocreotide), dietary modifications (e.g., MCT), pleural fluid drainage, and occasionally surgery.
Related Concept Videos
01:15Development of the Lymphatic System
869
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
869
01:16Lymphatic Vessels and Lymph Transport
4.0K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
4.0K
01:23Detailed Structure and Function of Lymph Nodes
2.0K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
2.0K
01:27Laminar Flow
1.1K
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
1.1K