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Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies

Bernard A Fox1,2,3, Walter J Urba1, Shawn M Jensen1

  • 1Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, Oregon.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 11, 2023
PubMed

Insights

Researchers found that cancer cells present noncanonical peptides (NCPs) that T cells do not react to. However, laboratory sensitization created NCP-specific T cells, offering potential new cancer therapies targeting shared antigens.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Cancer cells express Human Leukocyte Antigen (HLA) molecules presenting peptides.
  • Endogenous T cells often show limited reactivity to noncanonical peptides (NCPs) presented by tumors.
  • This suggests a potential immune evasion mechanism by cancer cells.

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