Related Experiment Video

Updated: Aug 3, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.0K

Is myopia accelerated in type 1 diabetes mellitus children? Analyses from the ocular parameters

Ying Xiao1, Yu Qian2, Chenhao Yang3

  • 1Department of Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, 399 Wanyuan Road, Shanghai, 201102, China.

BMC Ophthalmology
|April 11, 2023
PubMed

Insights

Children with type 1 diabetes mellitus (T1DM) and myopia exhibit thicker lenses and unchanged anterior chamber depth compared to healthy myopic children. This suggests impaired lens power compensation contributes to myopia progression in T1DM.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Endocrinology

Background:

  • Type 1 diabetes mellitus (T1DM) is a chronic condition affecting children.
  • Myopia prevalence and progression can be influenced by various factors.
  • Understanding ocular biometry differences in T1DM is crucial for pediatric eye care.

Purpose of the Study:

  • To compare ocular biometry parameters between children with T1DM and healthy children.
  • To analyze differences in myopia between T1DM and healthy pediatric populations.
  • To investigate the relationship between ocular structures and refractive error in T1DM.

Main Methods:

  • A case-control study involving T1DM and healthy children in China.
  • Participants categorized into four subgroups: myopia/non-myopia and T1DM/non-DM.
  • Ocular biometry measured included anterior chamber depth (ACD), lens thickness (LT), axial length (AL), keratometry (K), lens power (P), and spherical equivalent (SE).

Main Results:

  • Myopic T1DM children had thicker lenses (LT) and greater lens power (P) than myopic controls.
  • Myopic T1DM children showed longer axial length (AL) compared to non-myopic T1DM children.
  • In T1DM patients, longer AL, shallower ACD, and larger P were associated with decreased SE; similar associations were found in healthy controls.

Conclusions:

  • Anterior chamber depth and lens thickness in myopic T1DM children did not significantly differ from non-myopic T1DM children.
  • The lens in myopic T1DM children may not adequately compensate for axial length growth.
  • These findings provide evidence for accelerated myopia progression in children with T1DM.
Abstract

Keywords:
Lens powerLens thicknessMyopiaT1DM children

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.9K
Inducement and Evaluation of a Murine Model of Experimental Myopia07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

10.0K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
652
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
504
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
590
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
3.0K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K