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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

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Published on: February 12, 2016

Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study.

Lulu Sun¹, Daoxia Guo^1,2, Yiming Jia¹

¹Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, 199 Renai Road, Industrial Park District, 215123, Suzhou, Jiangsu Province, China.

Thrombosis Journal

|April 11, 2023

Summary

Higher intercellular adhesion molecule 4 (ICAM-4) levels are genetically linked to increased risks of ischemic stroke and cardioembolic stroke. Further research is needed to understand the underlying mechanisms and potential therapeutic targets.

Keywords:

Intercellular adhesion molecule 4 Ischemic stroke Mendelian randomization Risk

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Area of Science:

Genetics
Neurology
Cardiovascular Medicine

Background:

Experimental studies suggest intercellular adhesion molecule 4 (ICAM-4) involvement in ischemic stroke.
Population-based evidence linking ICAM-4 to ischemic stroke risk has been limited.
This study investigates genetically determined ICAM-4 levels and ischemic stroke risk.

Purpose of the Study:

To assess the association between genetically determined plasma ICAM-4 levels and the risk of ischemic stroke.
To examine the relationship between ICAM-4 and specific subtypes of ischemic stroke.
To provide population-based evidence on the role of ICAM-4 in stroke etiology.

Main Methods:

A two-sample Mendelian randomization (MR) analysis was conducted.
Eleven single-nucleotide polymorphisms associated with ICAM-4 were used as instrumental variables.
Genome-wide association study summary data for ICAM-4 and ischemic stroke from European and multi-ancestry cohorts were utilized.

Main Results:

Genetically determined higher ICAM-4 levels were significantly associated with increased risks of overall ischemic stroke (OR 1.04, P=0.003) and cardioembolic stroke (OR 1.08, P=0.003).
No significant associations were found between ICAM-4 and large artery stroke or small vessel stroke.
Sensitivity analyses confirmed the robustness of the findings and indicated no significant directional pleiotropy.

Conclusions:

Genetically determined plasma ICAM-4 is positively associated with the risks of ischemic stroke and cardioembolic stroke.
These findings highlight ICAM-4 as a potential factor in the development of specific stroke types.
Further research is warranted to elucidate the precise mechanisms and explore ICAM-4 as a therapeutic target.