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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Bacterial Flora of the Large Intestine01:29

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Clinical Assessment for Asthma:
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Related Experiment Video

Updated: Aug 3, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Study on Intestinal Flora and Asthma: Knowledge Graph Analysis Based on CiteSpace (2001-2021).

Hang Zheng1, Huan Dai1, Xiumei Yan1

  • 1Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Journal of Asthma and Allergy
|April 12, 2023
PubMed
Summary

Research on gut flora and asthma is increasing, focusing on mechanisms and treatments. Emerging areas include regulatory T cells, probiotics, and short-chain fatty acids, with SCFAs showing therapeutic promise.

Keywords:
Treg cellsallergychain fatty acidmicrobiotaprobiotics

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Area of Science:

  • Immunology
  • Microbiology
  • Pulmonology

Background:

  • Asthma is a chronic airway inflammatory disease.
  • Intestinal flora is a significant risk factor and concern in asthma pathogenesis.
  • Understanding the gut-lung axis is crucial for asthma research.

Purpose of the Study:

  • To review and analyze literature on intestinal flora and asthma from 2001-2021.
  • To summarize research directions and identify trends in this field.
  • To highlight emerging research hotspots and future directions.

Main Methods:

  • Bibliometric analysis using CiteSpace.
  • Analysis of 613 research articles from the Web of Science core collection.
  • Keyword analysis to identify research themes and evolution.

Main Results:

  • Research on gut flora and asthma has significantly increased, particularly in the last decade.
  • Research topics evolved from establishing the link to investigating mechanisms and treatments.
  • Key emerging areas include regulatory T (Treg) cells, probiotics, and short-chain fatty acids (SCFAs).

Conclusions:

  • Treg cells are critical in asthma pathogenesis linked to gut dysbiosis.
  • Probiotic supplements show no asthma risk reduction, while SCFAs supplements do.
  • Future research should focus on micro-level mechanisms and therapeutic applications of gut microbiota in asthma.