Cellular senescence in skin-related research: Targeted signaling pathways and naturally occurring therapeutic agents

Area of Science:

• Dermatology and aging research.
• Focus on cellular senescence and its impact on skin.

Background:

• Cellular senescence is a hallmark of aging, but its specific role in human skin is not fully understood.
• The skin, being the largest organ, is crucial for studying aging processes and potential interventions.
• Senolytic and senomorphic agents, including plant-derived compounds, are being explored to target aging in the skin.

Purpose of the Study:

• To review the multifaceted role of cellular senescence in skin physiology and pathology.
• To explore the signaling pathways involved in skin cellular senescence.
• To highlight the potential for developing targeted therapies for senescence-related skin conditions.

Main Methods:

• This is a review article, synthesizing existing research on skin cellular senescence.
• It covers aspects from basic physiology to pathological conditions and molecular signaling.
• Literature search and analysis of studies on senolytics, senomorphics, and plant-based derivatives in skin aging.

Main Results:

• Cellular senescence exhibits dual effects in the skin, with both beneficial and detrimental roles.
• Context-dependent therapies (prosenescent or antisenescent) may be required.
• Understanding molecular mechanisms is key to therapeutic development.

Conclusions:

• Cellular senescence plays a complex, context-dependent role in skin aging and health.
• Targeting senescence pathways offers potential for treating skin aging and disorders like impaired wound healing.
• Further research into molecular mechanisms can guide the development of novel senotherapeutics for dermatological applications.