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Neurite Orientation Dispersion and Density Imaging in Multiple Sclerosis: A Systematic Review
Homa Seyedmirzaei1, Fardin Nabizadeh2, Mohammad Hadi Aarabi3
1Tehran University of Medical Sciences, Tehran, Iran.
Journal of Magnetic Resonance Imaging : JMRI
|April 12, 2023
Summary
Neurite orientation dispersion and density imaging (NODDI) reveals microstructural changes in multiple sclerosis (MS) white and grey matter. This advanced diffusion technique enhances understanding of MS pathophysiology.
Area of Science:
- Neuroimaging
- Radiology
- Neurology
Background:
- Diffusion-weighted imaging (DWI) is crucial for studying multiple sclerosis (MS) alterations.
- Advanced diffusion models offer enhanced sensitivity for detecting subtle MS changes and early lesions.
- Neurite orientation dispersion and density imaging (NODDI) quantifies neurite morphology in grey (GM) and white matter (WM), improving DWI specificity.
Approach:
- This systematic review synthesized findings from 24 studies utilizing neurite orientation dispersion and density imaging (NODDI) in MS patients.
- NODDI quantifies specific neurite morphology in both grey matter (GM) and white matter (WM).
- Literature search conducted across PubMed, Scopus, and Embase databases.
Key Points:
- Consistent alterations in NODDI metrics were observed in MS patients compared to healthy controls.
- Specific findings include changes in neurite density index in WM and GM lesions.
- Alterations in isotropic volume fraction and neurite density index were noted in normal-appearing WM tissue.
Conclusions:
- NODDI demonstrates significant potential for unraveling microstructural alterations in MS.
- The findings contribute to a deeper understanding of the pathophysiological mechanisms underlying MS.
- NODDI may serve as a valuable tool for future MS research and clinical applications.
