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Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications
Rui Huang1, Cristina-Maria Hirschbiegel1, Victor Lehot1
1Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.
Advanced Materials (Deerfield Beach, Fla.)
|April 12, 2023
Summary
Bioorthogonal nanozymes combine transition metal catalysts with nanoscaffolds for in situ generation of bioactive molecules. This review highlights advances in designing these catalysts for targeted imaging and therapeutic applications.
Area of Science:
- Biotechnology
- Nanotechnology
- Catalysis
Background:
- Transition metal catalysts (TMCs) integrated into nanoscaffolds form nanocatalysts with enzyme-like functions.
- These nanocatalysts enable bioorthogonal chemistry, distinct from biological systems.
- Bioorthogonal nanozymes act as localized factories for producing bioactive molecules.
Purpose of the Study:
- To review recent advancements in bioorthogonal nanozymes.
- To focus on the modular design of nanomaterials and catalysts.
- To explore their synergistic roles in in situ uncaging of agents.
Main Methods:
- Co-engineering of transition metal catalysts and nanometric scaffolds.
- Modular design strategies for nanomaterials.
- Catalyst integration and functionalization.
Main Results:
- Nanocatalysts replicate enzymatic behavior, accessing unique bioorthogonal reactions.
- Co-engineered systems allow for precise, localized generation of bioactive molecules.
- Synergistic design enhances in situ uncaging of imaging and therapeutic agents.
Conclusions:
- Bioorthogonal nanozymes offer a powerful platform for targeted molecular generation.
- Modular design is crucial for optimizing nanozyme performance.
- These systems hold significant potential for advanced imaging and therapeutic strategies.
