Related Experiment Video

Updated: Aug 3, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Ping-Chieh Pao1,2, Jinsoo Seo1,2,3, Audrey Lee1,2

  • 1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|April 12, 2023
PubMed

Keywords:
Alzheimer’s diseaseCdk5neurodegenerative diseasetauopathy

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