Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Narcolepsy: a neuropathologic study.

S S Erlich, H H Itabashi

    Sleep
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Neuropathologic examination revealed focal gliosis in the pons and hypothalamus in a patient with idiopathic narcolepsy. These structural brain changes, previously undescribed in idiopathic narcolepsy, may explain the patient's symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients.

    Eye (London, England)·2012
    Same author

    Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy.

    Epilepsia·2000
    Same author

    Subdural neomembranes and sudden infant death syndrome.

    Journal of forensic sciences·1998
    Same author

    A comparison of the Bactec 9000MB system and the Septi-Chek AFB system for the detection of mycobacteria.

    Diagnostic microbiology and infectious disease·1997
    Same author

    Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature.

    Journal of neurology·1993
    Same author

    Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1.

    The Pediatric infectious disease journal·1990
    Same journal

    Sleep, circadian, and mental health in neurodivergent neurotypes: Lived experience perspective on the research landscape and roadmaps.

    Sleep·2026
    Same journal

    Nighttime light exposure is associated with metabolic dysfunction in schizophrenia: A cross-sectional analysis of the LENS study.

    Sleep·2026
    Same journal

    Sleep Need Outcompetes Preparation: Reframing Sleep Initiation Through Naturalistic Behaviour.

    Sleep·2026
    Same journal

    The Quest for Automated Pediatric Sleep Scoring: Are We There Yet?

    Sleep·2026
    Same journal

    Sex Differences in the Sleep Architecture and Sleep-Disordered Breathing in C57BL/6 J Mice.

    Sleep·2026
    Same journal

    Differential Effects of Prenatal Depression and Anxiety on Infant Sleep: Dual-Pathway Mechanisms Involving the HPA Axis and the Gut-Brain Axis.

    Sleep·2026
    See all related articles

    Area of Science:

    • Neuropathology
    • Neuroscience
    • Sleep Medicine

    Background:

    • Idiopathic narcolepsy is a chronic neurological disorder affecting sleep-wake cycles.
    • Previous research has not identified structural brain abnormalities in idiopathic narcolepsy.

    Observation:

    • A 48-year-old woman with a 1.5-year history of narcolepsy symptoms died suddenly.
    • Autopsy revealed an arachnoid cyst and focal gliosis in the ventrolateral caudal pons and periventricular anterior hypothalamus.

    Findings:

    • Microscopic examination identified focal gliosis in the pons and hypothalamus.
    • These neuropathologic findings are novel in the context of idiopathic narcolepsy.
    • The arachnoid cyst was not deemed the cause of the narcoleptic symptoms.

    Related Experiment Videos

    Implications:

    • This case suggests potential structural correlates for idiopathic narcolepsy.
    • Further research is needed to understand the etiology of pontine and hypothalamic gliosis in narcolepsy.
    • These findings may open new avenues for narcolepsy research and potential therapeutic targets.