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[Tiopronine and rheumatoid polyarthritis]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|January 1, 1986
Summary
Tiopronine effectively treats rheumatoid arthritis, showing identical efficacy to D-penicillamine at specific dosages. While side effects are similar, Tiopronine offers a valuable alternative for patients with a history of D-penicillamine adverse reactions.
Area of Science:
- Pharmacology
- Rheumatology
- Drug Development
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease requiring effective disease-modifying antirheumatic drugs (DMARDs).
- Thiol-containing drugs, like D-penicillamine, have been utilized in RA treatment.
- Tiopronine, a thiol-based compound, presents an alternative therapeutic option.
Purpose of the Study:
- To summarize clinical experience and literature data on Tiopronine for rheumatoid arthritis treatment.
- To compare the efficacy and safety of Tiopronine with D-penicillamine and placebo.
Main Methods:
- Review of authors' experience and existing literature.
- Analysis of data from controlled trials comparing Tiopronine to placebo.
- Analysis of data from controlled trials comparing Tiopronine to D-penicillamine.
Main Results:
- Tiopronine demonstrated effectiveness in treating rheumatoid arthritis.
- 1 gram of Tiopronine showed identical therapeutic action to 600 mg of D-penicillamine.
- Common side effects included rash, toxiderma, aguesia, and proteinuria, similar to D-penicillamine, and resolved upon discontinuation.
Conclusions:
- Tiopronine is an effective treatment for rheumatoid arthritis.
- It offers comparable efficacy to D-penicillamine.
- Tiopronine represents a valuable alternative, particularly for patients with a history of D-penicillamine side effects, as the risk of recurrence is not systematic.