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Irreversible ototoxic effect of erythromycin
Scandinavian Audiology
|January 1, 1986
Abstract:
Between 30 and 40 cases of reversible ototoxic side effects of erythromycin therapy have been reported previously but to our knowledge none with irreversible adverse reactions. A case of persistent tinnitus after intravenous erythromycin therapy is reported in the following.
Insights
Erythromycin therapy can cause reversible hearing issues. This report details a rare case of persistent tinnitus, an irreversible ototoxic side effect, following intravenous erythromycin treatment.
Area of Science:
- Ototoxicology
- Pharmacology
- Clinical Medicine
Background:
- Erythromycin is a widely used antibiotic.
- Ototoxic side effects, primarily reversible hearing loss, are known adverse reactions.
- Previous reports documented 30-40 cases of reversible ototoxicity.
Observation:
- A patient developed persistent tinnitus after receiving intravenous erythromycin.
- This adverse reaction was noted despite the general understanding of erythromycin's ototoxicity being reversible.
Findings:
- This case represents a potentially irreversible ototoxic adverse reaction to erythromycin.
- Persistent tinnitus is a significant and distressing symptom.
Implications:
- Highlights the risk of irreversible ototoxicity from erythromycin, contrary to previous literature.
- Suggests the need for increased vigilance regarding auditory monitoring during and after erythromycin therapy.
- Underscores the importance of reporting rare and severe adverse drug reactions.