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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Association Between Aortic Valve Calcification and Severity of Concomitant Aortic Regurgitation in Patients With

Fumi Yokohama1, Yoichi Takaya1, Keishi Ichikawa1

  • 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.

Circulation Journal : Official Journal of the Japanese Circulation Society
|April 12, 2023
PubMed

Insights

Aortic valvular calcification (AVC) severity correlates with concomitant aortic regurgitation (AR) in patients with severe aortic stenosis (AS). Increased AVC may cause or worsen AR, impacting disease progression.

Area of Science:

  • Cardiology
  • Radiology
  • Valvular Heart Disease

Background:

  • Severe aortic stenosis (AS) often coexists with aortic regurgitation (AR).
  • The relationship between aortic valvular calcification (AVC) and AR severity in AS patients is not well understood.

Purpose of the Study:

  • To investigate the association between AVC and the severity of concomitant AR in patients with severe AS.

Main Methods:

  • Retrospective review of 95 patients with severe AS.
  • Transthoracic echocardiography and multidetector computed tomography (MDCT) were performed within 1 month.
  • Patients were categorized by AR severity: none/trivial (n=27), mild (n=53), and moderate (n=15).

Main Results:

  • Aortic valvular calcification score (AVCS) and volume (AVCV) significantly increased with AR severity (P=0.014).
  • Indexed AVCS and AVCV also showed a significant positive correlation with AR severity (P=0.004).

Conclusions:

  • AR severity in severe AS patients correlates with MDCT-measured AVCS and AVCV.
  • AVC may be a causative factor for concomitant AR, potentially worsening the disease condition.
Abstract

Keywords:
Aortic regurgitationAortic stenosisAortic valve calcification

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