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Cimetidine utilization in Denmark 1977-1981.

K Schmidt, J Mosbech, E Worsøe

    Scandinavian Journal of Social Medicine
    |January 1, 1986
    PubMed
    Summary
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    Cimetidine (Tagamet) use in Denmark surged post-registration but did not impact hospital ulcer disease rates. Geographic variations in prescribing patterns were observed without clear explanations.

    Area of Science:

    • Pharmacoeconomics
    • Gastroenterology
    • Public Health

    Background:

    • Cimetidine (Tagamet) was introduced in Denmark in September 1977.
    • The study examines drug utilization patterns from 1977 to 1981, preceding general reimbursement in July 1981.

    Purpose of the Study:

    • To describe the utilization patterns of cimetidine in Denmark.
    • To analyze prescription trends and their correlation with ulcer disease incidence and diagnosis.

    Main Methods:

    • Analysis of 19,154 individual drug reimbursement applications to the National Board of Health.
    • Examination of application rates per 100,000 inhabitants, age-specific rates, and geographical variations.

    Main Results:

    • Cimetidine application rates increased significantly from 1978 to 1980, then slightly decreased in 1981.

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  • Hospital utilization for ulcer disease remained constant despite increased cimetidine use.
  • Duodenal ulcers accounted for half of applications, gastric ulcers for a third, with only 50% of gastric ulcers endoscopically diagnosed.
  • Peak application rates were in the 50-69 age group, with notable geographical variations unexplained by health status or specialty interest.
  • Conclusions:

    • Rapid cimetidine adoption did not alter overall hospital ulcer disease burden.
    • Diagnostic practices for gastric ulcers, particularly endoscopy use, appear suboptimal.
    • Significant geographical variations in cimetidine prescribing warrant further investigation.