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Updated: Aug 3, 2025
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
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Rotating Gantries Provide Individualized Beam Arrangements for Charged Particle Therapy.
Siven Chinniah1, Amanda J Deisher2, Michael G Herman2
1Mayo Clinic Alix School of Medicine, Jacksonville, FL 32224, USA.
Cancers
|April 13, 2023
Summary
Highly individualized proton therapy plans for carbon ion radiotherapy-eligible patients utilize a wide range of beam angles. A rotating gantry is optimal for achieving diverse beam arrangements in proton therapy.
Area of Science:
- Medical Physics
- Radiation Oncology
- Radiotherapy Technology
Background:
- Carbon ion radiotherapy (CIRT) offers potential advantages for specific cancers.
- Proton therapy planning requires precise beam angle selection for optimal dose delivery.
- Individualized treatment plans are crucial for maximizing tumor coverage and minimizing dose to healthy tissues.
Purpose of the Study:
- To evaluate the distribution and utilization of beam angles in proton therapy for patients eligible for CIRT.
- To determine if specific beam angle arrangements are favored across different anatomical sites.
Main Methods:
- Retrospective analysis of 467 patients treated with pencil beam scanning intensity modulated proton therapy (2015-2020).
- Evaluation of treatment plans generated using a 190° rotating gantry and robotic patient positioning.
- Grouping and histogram analysis of utilized beam angles by anatomical treatment site.
Main Results:
- A total of 484 plans and 1196 unique beam angles were analyzed.
- The most frequently used beam angles were 0° and 180°.
- Most anatomical sites demonstrated a wide distribution of beam angles, except for esophageal cancers (unimodal) and pancreas cancers (modest grouping).
Conclusions:
- The extensive use of diverse beam angles supports the efficacy of a rotating gantry system.
- A rotating gantry facilitates highly individualized beam arrangements for CIRT-eligible patients.
- Proton therapy planning benefits from a wide range of beam angle options for complex cases.
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