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Related Concept Videos

Odds Ratio01:09

Odds Ratio

196
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
196

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Related Experiment Video

Updated: Aug 3, 2025

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

158

Lymph Node Log-Odds Ratio Accurately Defines Prognosis in Resectable Non-Small Cell Lung Cancer.

Michal Benej1, Thomas Klikovits1, Tibor Krajc1

  • 1Department of Thoracic Surgery and Karl-Landsteiner-Institute, Clinic Floridsdorf, 1210 Vienna, Austria.

Cancers
|April 13, 2023
PubMed
Summary
This summary is machine-generated.

The lymph node log-odds ratio (LN-LOR) is a significant prognostic factor for overall survival (OS) in operable non-small cell lung cancer (NSCLC). This metric may better reflect disease behavior than the traditional LN ratio, supporting extensive lymph node dissection.

Keywords:
lobectomylog-odds ratiolymph node stagingnon-small cell lung cancerprognosissurgery

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Biostatistics

Background:

  • The lymph node ratio (LN ratio) is a known prognostic indicator in non-small cell lung cancer (NSCLC).
  • The lymph node log-odds ratio (LN-LOR) incorporates the total number of resected lymph nodes, potentially offering a more comprehensive prognostic assessment.
  • Evaluating novel prognostic factors is crucial for refining treatment strategies in operable NSCLC.

Purpose of the Study:

  • To assess the prognostic value of the lymph node log-odds ratio (LN-LOR) in patients with operable non-small cell lung cancer (NSCLC).
  • To compare the predictive power of LN-LOR against traditional lymph node staging.
  • To determine if LN-LOR is an independent prognostic factor for overall survival (OS) in NSCLC.

Main Methods:

  • Retrospective analysis of 944 patients with NSCLC undergoing curative intent lobectomy at two high-volume centers.
  • Dichotomization of LN-LOR based on its impact on overall survival (OS).
  • Correlation of LN-LOR with N descriptors, clinical variables, and survival outcomes using multivariable Cox regression.

Main Results:

  • A significant cut-off for LN-LOR at -0.34 was identified, discriminating patients by OS (p < 0.001).
  • LN-LOR risk groups showed distinct survival outcomes, irrespective of lymph node anatomical location.
  • Age, sex, histological subtype, pathological stage, and LN-LOR risk groups were identified as independent prognostic factors for OS.

Conclusions:

  • LN-LOR is significantly associated with OS in resectable NSCLC.
  • LN-LOR may provide a better reflection of the disease's biological behavior compared to the traditional LN ratio.
  • These findings support the potential benefit of extensive lymph node dissection in NSCLC management.