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Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

Fatemeh Arzanforoosh1,2, Sebastian R van der Voort1,2, Fatih Incekara1,3

  • 1Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

Cancers
|April 13, 2023
PubMed

Insights

Vessel size imaging (VSI) MRI effectively characterizes microvasculature in non-enhancing adult gliomas. This technique differentiates subtypes like Oligo, Astro, and GBM, offering insights into their distinct vascular features.

Area of Science:

  • Neuroimaging
  • Oncology
  • Vascular Biology

Background:

  • Adult-type diffuse gliomas are classified into subtypes based on genetic markers and enhancement patterns on MRI.
  • Non-enhancing gliomas present diagnostic challenges, necessitating advanced imaging techniques for characterization.
  • Understanding microvasculature is crucial for glioma subtyping and treatment strategies.

Purpose of the Study:

  • To utilize vessel size imaging (VSI) MRI to characterize microvasculature in three subtypes of adult-type diffuse glioma lacking enhancement.
  • To compare VSI-derived quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size across glioma subtypes.
  • To correlate MRI findings with histopathological analysis of microvasculature.

Main Methods:

  • Vessel size imaging (VSI) MRI was performed on 38 patients with non-enhancing gliomas.
  • Patients were categorized into Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt) subtypes.
  • Histopathological analysis of microvasculature was conducted on tissue samples from 21 patients.
  • Statistical analysis (ANOVA, Kruskal-Wallis) compared VSI and histology features across subtypes.

Main Results:

  • Significant differences in CBV, µCBV, and vessel size were observed between the three glioma subtypes (p < 0.01).
  • Astro (IDH-mut) showed lower CBV and µCBV than Oligo (p = 0.004, p = 0.001) and larger vessel size than GBM (p = 0.01).
  • GBM (IDH-wt) exhibited more irregular vessel shapes compared to other subtypes (p < 0.05).

Conclusions:

  • VSI MRI provides valuable insights into the microvasculature of non-enhancing adult glioma subtypes.
  • The technique demonstrates potential for differentiating between Oligo, Astro, and GBM gliomas based on vascular characteristics.
  • Further research is warranted to explore the specificity of VSI for glioma subtype differentiation.
Keywords:
cerebral blood volumegliomamicrovesselmolecular typingperfusion imagingvessel size imaging

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