Related Experiment Video

Updated: Aug 3, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19

Ahmed M E Elkhalifa1,2, Naveed Nazir Shah3, Zaid Khan3

  • 1Department of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh 11673, Saudi Arabia.

Healthcare (Basel, Switzerland)
|April 13, 2023
PubMed

Insights

Patients with hypercreatinemia (elevated creatinine) hospitalized with COVID-19 faced higher risks of severe illness, intensive care unit (ICU) admission, and death. Managing kidney function may improve COVID-19 patient outcomes.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Hypercreatinemia, an indicator of kidney dysfunction, is increasingly recognized as a potential comorbidity in COVID-19 patients.
  • Understanding the impact of pre-existing kidney issues on COVID-19 severity and outcomes is crucial for clinical management.

Purpose of the Study:

  • To investigate the clinical presentation and outcomes of COVID-19 patients with hypercreatinemia upon hospital admission.
  • To identify risk factors associated with mortality in COVID-19 patients with elevated creatinine levels.

Main Methods:

  • A retrospective observational study involving 1668 COVID-19 patients hospitalized between March 2020 and April 2021.
  • Analysis of clinical data, including intensive care unit (ICU) admission, disease severity, mechanical ventilation, and mortality rates.
  • Multivariable analysis to determine independent risk factors for in-hospital mortality.

Main Results:

  • Out of 1668 patients, 339 presented with hypercreatinemia.
  • Hypercreatinemic patients showed significantly higher rates of ICU admission, severe COVID-19, mechanical ventilation, and all-cause mortality.
  • Elevated creatinine, age, IL-1, D-Dimer, and Hs-CRP were independent predictors of in-hospital mortality, with creatinine strongly associated (HR 5.34).

Conclusions:

  • Hypercreatinemia is a significant predictor of poor outcomes in hospitalized COVID-19 patients.
  • Improving kidney function may be a therapeutic target to enhance outcomes for COVID-19 patients.
  • Early identification and management of kidney dysfunction are vital in COVID-19 care.

Keywords:
COVID-19hypercreatinemicintensive caremechanical ventilationoutcome

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

734
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-1908:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
48
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
47
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.3K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
161
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
49
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
45