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Updated: Aug 3, 2025
09:14
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
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Multifunctional Lysyl Oxidases
1The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
International Journal of Molecular Sciences
|April 13, 2023
Summary
Lysyl oxidases (LOX) are multifunctional proteins crucial for various biological processes. This special issue explores diverse research on LOX family members (LOXL1-LOXL4) to advance understanding of their complex roles.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Lysyl oxidases (LOX) are copper-dependent amine oxidases encoded by five related genes (LOX, LOXL1-LOXL4).
- These enzymes play critical roles in extracellular matrix (ECM) crosslinking, influencing tissue structure and integrity.
- Emerging evidence highlights diverse non-canonical functions beyond ECM remodeling.
Discussion:
- This special issue compiles research on the multifaceted nature of lysyl oxidases.
- It covers various approaches to investigate LOX protein family members.
- Understanding LOX biology is essential for comprehending tissue development, homeostasis, and disease.
Key Insights:
- Lysyl oxidases exhibit diverse functions extending beyond their canonical role in collagen and elastin crosslinking.
- The LOX family members (LOX, LOXL1-LOXL4) are implicated in various cellular processes, including cell proliferation, migration, and signaling.
- Investigating LOX proteins requires multidisciplinary approaches to fully elucidate their biological significance.
Outlook:
- Future research will likely focus on targeted therapeutic strategies modulating LOX activity in diseases like cancer and fibrosis.
- Further exploration of non-canonical LOX functions will reveal new insights into cellular regulation.
- Continued investigation into the LOX family's role in development and aging is warranted.
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