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Necrotizing arteritis associated with blastomycosis.

M C Houston, J M Marion, W A Curry

    Southern Medical Journal
    |April 1, 1986
    PubMed
    Summary
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    A patient with a probable pulmonary blastomycosis fungal infection and skin necrotizing arteritis experienced resolution of lesions after amphotericin B treatment. This case highlights effective antifungal therapy for complex fungal infections.

    Area of Science:

    • Mycology
    • Pulmonology
    • Dermatology

    Background:

    • Blastomycosis is a fungal infection caused by Blastomyces dermatitidis, primarily affecting the lungs.
    • Necrotizing arteritis is a rare inflammatory condition affecting blood vessels, which can manifest in the skin.

    Observation:

    • A patient presented with cavitary pulmonary fungal infection, suspected to be blastomycosis.
    • The patient also exhibited necrotizing arteritis of the skin, a less common manifestation.

    Findings:

    • Pulmonary lesions consistent with blastomycosis were identified.
    • Skin biopsies confirmed necrotizing arteritis.
    • Treatment with amphotericin B led to the resolution of both pulmonary and cutaneous lesions.

    Implications:

    Related Experiment Videos

    • This case underscores the importance of considering fungal infections like blastomycosis in patients with cavitary lung disease and concurrent vasculitis.
    • Amphotericin B remains an effective treatment option for severe cases of blastomycosis with extra-pulmonary involvement.
    • Early diagnosis and appropriate antifungal therapy are crucial for favorable outcomes in patients with disseminated blastomycosis.